Dose-Dependent Effects of Mumie (Shilajit) Extract on Platelet Count in Dogs
Keywords:
Mumie extract, Shilajit, Platelets, Thrombocytopenia, Hemostasis, dogs, Natural compounds, Traditional medicine.Abstract
Platelets play a critical role in hemostasis, and their number and function are key determinants of bleeding risk. Mumie (shilajit), a natural herbo-mineral substance used in traditional medicine, has been suggested to influence various physiological processes. However, its effects on platelet parameters remain poorly understood.This study aimed to evaluate the effect of mumie extract on platelet count in dogs at varying dosages and time intervals following administration.Healthy adult dogs were administered mumie orally at doses of 10, 25, and 50 mg/kg. Platelet counts were measured before administration (baseline), and at 1 and 2 hours post-administration. Data were analyzed for statistical significance using paired t-tests.
Downloads
References
1. Wilson E, Rajamanickam GV, Dubey GP, et al. 2011. Review on shilajit used in traditional Indian medicine. J Ethnopharmacol 136: 1–9.
2. Schepetkin I, Khebnikov A, Kwon BS. 2002. Medical drugs from humus matter: focus on mumie. Drug Devel Res 57: 140–159.
3. Agarwal SP, Khanna R, Karmarkar R, Anwer MK, Khar RK. 2007. Shilajit: a review. Phytother Res 21: 401–405.
4. Bucci LR. 2000. Selected herbals and human exercise performance. Am J Clin Nutr 72[2 suppl]: 624S-636S.
5. Kwon, B.S., Khlebnikov, A.I., Schepetkin, I.A., Woo, S.B., 2004. Fulvic acid fractions from mumie. In: Proceedings Volume of the 8th Rusian-Korean International Symposium , Korus 3, pp. 352–355
6. Garedew, A., Feist, M., Schmolz, E., Lamprecht, I., 2004. Thermal analysis of mumiyo, the legendary folk remedy from the Himalaya region. Thermochimica Acta 417, 301–309
7. Frolova N, Kiseleva L, Tatiana. Chemical composition of mumijo and methods for determining its authenticity and quality [a review]. Pharma Chem J. 1996;30[8]:543-7.
8. Stohs SJ, Singh K, Das A, Roy S, Sen CK. 12-Energy and Health Benefits of Shilajit. In: Bagchi D, editor. Sustained Energy for Enhanced Human Functions and Activity. Academic Press; 2017. p. 187-204
9. Ghosal S, Lal J, Singh SK, Goel RK, Jaiswal AK, Bhattacharya SK. The need for formulation of Shilajit by its isolated active constituents. Phytother Res. 1991;5[5]:211-6
10. Golebiewska EM, Poole AW. Platelet secretion: from haemostasis to wound healing and beyond. Blood Rev 2015;29:153–62.
11. Estcourt LJ, Stanworth SJ, Murphy MF. Platelet transfusions for patients with haematological malignancies: who needs them? Br J Haematol 2011;154:425–40.
12. Slichter SJ, Kaufman RM, Assmann SF, McCullough J, Triulzi DJ, Strauss RG, et al. Dose of prophylactic platelet transfusions and prevention of hemorrhage. N Engl J Med 2010;362:600–13.
13. Uhl L, Assmann SF, Hamza TH, Harrison RW, Gernsheimer T, Slichter SJ. Laboratory predictors of bleeding, and effect of platelet and RBC transfusions on bleeding outcomes, in the PLADO Trial. Blood 2017;130:1247–58.
14. Heddle NM, Cook RJ, Sigouin C, Slichter SJ, Murphy M, Rebulla P, et al. A descriptive analysis of international transfusion practice and bleeding outcomes in patients with acute leukemia. Transfusion 2006;46:903–11.
15. Vinholt PJ, Frederiksen H, Hvas AM, Sprogoe U, Nielsen C. Measurement of platelet aggregation, independently of patient platelet count: a flow-cytometric approach. J Thromb Haemost 2017;15:1191–202
16. Vinholt PJ, Knudsen GH, Sperling S, Frederiksen H, Nielsen C. Platelet function tests predict bleeding in patients with acute myeloid leukemia and thrombocytopenia. Am J Hematol 2019;94:891–901.
