RELATIONSHIP OF ORGAN-SPECIFIC AUTOIMMUNE PATHOLOGY OF THE THYROID GLAND WITH INORGANIC AUTOIMMUNE RHEUMATIC DISEASES

Urakov Jamshid Rustamovich

Department of Rehabilitation and Sports Medicine Bukhara State Medical Institute

##semicolon## thyroid gland, thyroid hormones, antibodies to thyroid gland hormones, rheumatoid arthritis.


सार

The problem of a pathology of a thyroid gland at rheumatic diseases, in particular at rheumatoid arthritis, remains actual and to this day. The work purpose was studying antitelogenesis to thyroid hormones at patients with mixt autoimmune pathology. In whey of blood of patients with RA and autothyroid pathology are found out antibodies (AB) to Т3 and Т4, their concentration correlates with activity of pathological process. It is shown, that level AB to Т3 and Т4 authentically differs from the maintenance of the given antibodies in whey of blood of healthy faces. Level of antibodies to thyroid hormones can be considered as the criterion predicting development of pathology of a thyroid gland at patients with RA.


##submission.citations##

Badokin V.V., Gilyarevsky S.R. Are there any peculiarities in the course of rheumatoid arthritis when it is combined with autoimmune thyroiditis? Honey. help 1999; 4: 16–18.

Baimukhamedova R.O. Age-related and endocrine aspects of RA: Author's abstract. dis. ...dra honey. Sci. M., 1993.

Beldanova M.V., Skalny A.A. Biological role of the thyroid gland and its hormones. Wedge. and expert thyroidol 2007; 3(1): 24–32.

Volt R. Autoimmune diseases of the thyroid gland // Diseases of the thyroid gland / Ed. L. I. Braverman. M.: Medicine, 2000.

Emelyanov N.N., Rusanova O.A., Paramonova O.V. and others. Immunosorption of autothyroid antibodies as a method of treating chronic autoimmune thyroiditis. Doctor-graduate student 2010; 6.1(43): 122–128.

Myagkova M.A. Natural antibodies to hormones. M., Materia-Medica, 2001.

Paramonova O.V. Clinical and diagnostic value of determining antibodies to thyroid hormones in patients with rheumatoid arthritis in combination with damage to the thyroid gland using magnetically controlled immunosorbents: Abstract of thesis. ….cand. med. sc. Volgograd, 2008.

Paramonova O.V., Gontar I.P., Aleksandrov A.V., Romanov A.I. Clinical and diagnostic value of determining antibodies to thyroid hormones in patients with rheumatoid arthritis. Vestn. VolSMU 2010; 3 (35): 72–75.

Serebryakov V.G. Autoimmune pathology of the thyroid gland in rheumatoid arthritis and systemic lupus erythematosus. Rheumatology 1991; 1:30–33.

Serebryakov V.G. Rheumatoid arthritis and systemic lupus erythematosus, combined with damage to the thyroid gland: Abstract of thesis. ...cand. honey. Sci. M., 1990 p.

Deighton S. M., Fay A., Walker D. J. Rheumatoid arthritis in thyroid disease positive and negative same sexed sibships. Brit. J. Rheum. 1992; 31 (1): 13–17.

Salvi M., Fukazawa H., Bernard N. et al. Role of autoantibodies in the pathogenesis and association of endocrine autoimmune disorders. Endocr. Rev. 1988; 9:450–466.

Peter J.B. Thyroid autoimmunity: in search of antibodies. Diagn. Med. 1981; 4: 19–27.

Shiroky J. V., Cohen M., Ballachev M. L. et al. Thyroid dysfunction in rheumatoid arthritis: a controlled prospective survey. Ann. rheum. Dis. 1993; 52:454–456.

Weetman A.P. The Spectrum of Autoimmunity in Thyroid Disease, Thyroid Intern. 2005; 1:1–15.

Zweig M.H. ROC Plots: A Fundamental Evaluation Tool in Clinical Medicine / M.H. Zweig, G. Campbell. Clin. Chem. 1993; 39(4):561–577.