CLINICAL FEATURES OF COMMON INFECTIONS IN CHILDREN UNDER 14 YEARS OF AGE WITH HIV
Keywords:
HIV-associated nephropathy, antiretroviral therapy (ART), cystatin-C, glomerular filtration rate, microalbuminuria, nephrotoxicity.Abstract
Renal impairment against the background of HIV infection (HIV-associated nephropathy) is a major non-infectious factor exacerbating disease outcomes. This study aims to optimize the early diagnosis of renal pathologies and antiretroviral therapy (ART) regimens in HIV-infected patients. Observations demonstrated that subclinical screening using cystatin-C and microalbuminuria, combined with a transition to low-nephrotoxicity ART regimens, significantly reduces the risk of developing renal failure. The conceptual findings serve as a crucial clinical platform for refining regional nephrological and infection control protocols and improving patients' quality of life.
Downloads
References
1. Atabekov N.S., Ubaydullayeva N.N. O'zbekiston Respublikasida OIV infeksiyasini profilaktika qilish va davolash bo'yicha milliy klinik qo'llanma. Toshkent: Sog'liqni saqlash vazirligi nashriyoti; 2020.
2. Mustafayeva O.A., Ergasheva M.Yu. OIV infeksiyasi fonida noinfeksion asoratlarning patogenetik va klinik xususiyatlari. Infeksiya, immunitet va farmakologiya jurnali. 2022;3(2):45-52.
3. G'afforov X.A., Yusufjonov D.D. Andijon viloyatida OIV/OITS va yondosh patologiyalarni boshqarish strategiyalari. Andijon Davlat Tibbiyot instituti xabarnomasi. 2023;2(1):33-39.
4. Xudayberdiyev Sh., Karimov U. Antiretrovirus dori vositalarining nefrotoksiklik profili tahlili. Tibbiyotda innovatsiyalar jurnali. 2021;4(1):112-118.
5. Ruzmetova Z.K., Ismoilov K.I. OIV-assotsirlangan nefropatiyada erta diagnostika biomarkerlarining o'rni. Tibbiyot va zamonaviylik jurnali. 2023;1(3):22-29.
6. Sharipov A.M., To'xtayev B.A. Yuqumli kasalliklar va ichki a'zolar patologiyasi: OIV infeksiyasida tizimli zararlanishlar. Toshkent: Ilm-ziyo nashriyoti; 2021.
7. Sadikova D.I. O'zbekiston demografik sharoitida bemorlarda ARVT ga moyillik va toksik ta'sirlar tahlili. O'zbekiston tibbiyot jurnali. 2022;8(2):77-84.
8. O'zbekiston Respublikasi Sog'liqni saqlash vazirligi. OIV infeksiyasida opportunistik va noinfeksion kasalliklarni davolash standartlari to'g'risidagi buyruq. Toshkent; 2021.
9. Mirzayeva G.T., Xolmamatov B. ARVT qabul qilayotgan bemorlarda koptokchalar filtratsiyasi dinamikasi monitoringi. Farg'ona vodiysi tibbiyot xabarnomasi. 2024;5(1):55-61.
10. Qurbonov A.X. OITSga qarshi kurashda komorbid holatlar: milliy tajriba va klinik tavsiyalar. Toshkent: Abu Ali ibn Sino nomidagi tibbiyot nashriyoti; 2021.
