PERIODONTITIS AS A MANIFESTATION OF SYSTEMIC DISEASE
Abstract
Chronic periodontitis is a multifactorial inflammatory disease characterized by progressive destruction of periodontal tissues and alveolar bone. While microbial biofilm initiates the inflammatory process, individual variability in disease progression suggests a significant contribution of host-related factors, particularly genetic determinants of immune response. Pro-inflammatory cytokines play a key role in regulating periodontal inflammation, and genetic polymorphisms affecting cytokine expression may influence disease severity and clinical outcomes.
Downloads
References
1. Budtz-Jørgensen, E.; Lombardi, T. Denture stomatitis revisited. Periodontology 2000 2018, 78, 254–261.
2. Felton, D.A. Complete edentulism and comorbid diseases: An update. Journal of Prosthodontics 2016, 25, 5–20.
3. Grigoriadou, M.E.; Koutayas, S.O.; Madianos, P.N.; Strub, J.R. Interleukin-1 as a genetic marker for periodontal disease. Journal of Clinical Periodontology 2010, 37, 517–523.
4. Napimoga, M.H.; Nunes, L.H.; Maciel, A.A.; et al. Possible involvement of IL-1β polymorphism in chronic periodontitis. Journal of Oral Science 2014, 56, 13–19.
5. Tian, Y.; Feng, P.; Wang, Y.; et al. Association between TNF-α gene polymorphism and chronic periodontitis: A meta-analysis. Journal of Periodontal Research 2013, 48, 298–305.
6. Ayazi, G.; Pirayesh, M. Genetic polymorphisms of cytokines and susceptibility to periodontal disease. Journal of Dental Research, Dental Clinics, Dental Prospects 2013, 7, 8–15.
7. Feng, P.; Tian, Y.; Chen, Z.; et al. Association of TNF-α polymorphisms with periodontal disease risk: Evidence from a population-based study. Inflammation Research 2014, 63, 901–908.
8. Casado, P.L.; Villas-Boas, R.; de Mello, W.; et al. Genetic susceptibility in chronic periodontitis: A systematic review. Journal of Periodontology 2015, 86, 99–111.
9. Petrin, A.N.; Tsarev, V.N. Cytokine gene polymorphisms in inflammatory diseases: Clinical significance. Infection and Immunity 2011, 79, 3381–3389.
10. Gulmukhamedov, P.B. Clinical and molecular-genetic aspects of periodontitis pathogenesis. PhD Thesis Abstract, Tashkent State Dental Institute, Tashkent, Uzbekistan, 2019.
11. Hasanov, L.E.; Abdullaeva, N.R.; Mirkhoshimova, M.F. Genetic markers of periodontal inflammation in Central Asian populations. Stomatologiya 2017, 1, 15–19.
12. Safarov, M.T.; Dadabaeva, M.U.; Asemova, S.A.; et al. Modern aspects of mathematic modeling in dental implantation. Science and Education: Problems and Prospects 2020, 354–359.
13. Xabilov, N.L.; Xabilov, B.N.; Sharipov, S.S.; et al. Plant-based complexes in dentistry. Journal of New Century Innovations 2024, 66, 203–209.
14. World Health Organization. Oral health fact sheet. WHO, Geneva, Switzerland, 2012. Available online: https://www.who.int (accessed on Day Month Year).
