CLINICAL PHARMACOLOGICAL APPROACH TO THE RATIONAL USE OF ANTIDEPRESSANT DRUGS IN AUTOIMMUNE DISEASES
Keywords:
Autoimmune diseases; antidepressants; clinical pharmacology; neuroinflammation; personalized therapy; drug interactions; cytokine modulation; rational pharmacotherapy.Abstract
This article explores the clinical-pharmacological principles underlying the rational use of antidepressant drugs in patients with autoimmune diseases. Autoimmune disorders are frequently accompanied by chronic inflammation, neuroimmune dysregulation, and a high prevalence of comorbid depression, making the choice of antidepressant therapy clinically complex. The paper examines pharmacodynamic interactions between antidepressants and immunomodulatory medications, highlights the importance of personalized medicine, evaluates the safety profile of various antidepressant classes, and provides practical recommendations for optimizing treatment outcomes.
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