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Published
2025-06-12
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Articles
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How to Cite
Comparative Anticoagulant Activity of Afghan, Indian, Chinese, and Transbaikal Mumiyo in a Rat Model
Boltabaeva Dilbarkhon Fayzirakhmanovna
Andijan State Medical Institute, Department of Pharmacology, Clinical Pharmacology, and Medical Biotechnology.
Keywords: Mumiyo, blood coagulation, Lee-White method, Natural compounds, Afghan mumiyo, Indian mumiyo, Chinese mumiyo, Transbaikal mumiyo, Traditional medicine.
Abstract
This study aimed to compare the anticoagulant effects of different regional types of mumiyo Afghan, Indian, Chinese, and Transbaikal on blood coagulation in vitro using the Lee-White method in a rat model.
Aqueous solutions of each mumiyo type were prepared at concentrations of 1, 2, 5, and 10 mg/mL. Whole blood samples were collected from healthy Wistar rats and exposed to the mumiyo solutions. Clotting times were measured using the Lee White method at 37°C. A control group with no mumiyo treatment was used for baseline comparison. Each test was conducted in triplicate.
Chinese mumiyo demonstrated minimal effect on clotting time, while Afghan, Indian, and Transbaikal mumiyo showed significant anticoagulant activity in a dose-dependent manner. At concentrations of 2–5 mg/mL, clotting times were prolonged by up to 9–30 minutes, with the most pronounced effect observed in Afghan mumiyo at 10 mg/mL (90 minutes).
References
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