Multidisciplinary Journal of Science and Technology

AGE-RELATED CHANGES IN ALCOHOLIC LIVER CIRRHOSIS: IMPLICATIONS FOR SKELETAL MUSCLE MASS AND OVERALL PROGNOSIS IN OLDER ADULTS

M. O. Koshimuratova

Tashkent Medical Academy, Tashkent, Uzbekistan

K. N. Babaev

Tashkent Medical Academy, Tashkent, Uzbekistan

Keywords: Alcohol use, aging, older adults

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Abstract

Alcohol use is increasing among adults aged 65 and older, and the size of this population is expanding rapidly. Aging is associated with systemic inflammation, sleep disturbances, cancers, cognitive decline, and increased risk of injury and death from falls and other accidents. Alcohol misuse exacerbates and accelerates these age-related changes. Older drinkers are more sensitive to acute alcohol-induced impairments in memory, coordination, reaction time, and driving performance. Oxidative stress and DNA damage resulting from chronic heavy alcohol consumption contribute to an increased risk of cancer, liver disease, and cardiovascular disease. Medication use increases with age, and many medications prescribed to older adults can negatively interact with alcohol. The rapid expansion of the population aged 65 and older, combined with higher levels of alcohol use and alcohol use disorder (AUD) in the Baby Boomer cohort, could significantly increase the burden of alcohol on the healthcare system. Screening and brief intervention for hazardous alcohol use among older patients, along with education about potential interactions with medications, could substantially reduce the risk of alcohol-related harms, but this approach is currently underutilized.

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