PDF
ZENODO
Published
2026-04-21
Section
Articles
How to Cite
How to Cite
THE CARDIAC CONDUCTION SYSTEM: HISTOPHYSIOLOGICAL CHARACTERISTICS OF THE GIS BUNDLE AND PURKINJE FIBERS
Eshboyeva Marjona
Tashkent State Medical University, Termez Branch, Faculty of General Medicine, 1st-year student
Keywords: cardiac conduction system, pacemaker cells, cardiac automatism, bundle of His, Purkinje fibers, depolarization, ion channels, heart rhythm, arrhythmia, block, electrophysiology, myocardium, impulse conduction, sinoatrial node, atrioventricular node.
Abstract
This article provides a scientific analysis of the histophysiological characteristics of the cardiac conduction system, specifically the bundle of His and Purkinje fibers, as well as the activity of pacemaker cells that form the basis of cardiac automatism. The study examines the mechanisms of cardiac impulse generation and conduction, their physiological foundations at the cellular level, and the significance of ion channel activity. Disruptions of cardiac conduction, particularly the causes of blocks and arrhythmias, are explained at cellular and molecular levels. The article also reviews modern approaches to the detection of cardiac rhythm disorders and their clinical assessment in medical practice.
References
1. Guyton and Hall Textbook of Medical Physiology / A.C. Guyton, J.E. Hall. – Philadelphia: Elsevier, 2021.
2. Review of Medical Physiology / W.F. Ganong. – New York: McGraw-Hill Education, 2020.
3. Color Atlas of Physiology / A. Despopoulos, S. Silbernagl. – Stuttgart: Thieme, 2019.
4. Histology: A Text and Atlas / M.H. Ross, W. Pawlina. – Philadelphia: Wolters Kluwer, 2020.
5. Medical Histology / B. Young, G. O’Dowd, P. Woodford. – Elsevier, 2018.
6. Cardiovascular Physiology Concepts / R.E. Klabunde. – Philadelphia: Lippincott Williams & Wilkins, 2017.
7. World Health Organization. Cardiovascular diseases (CVDs): Key facts. – Geneva, 2023.
8. American Heart Association. Heart conduction system and arrhythmias. – 2022.
