International conference on multidisciplinary science

SYNTHESIS OF THE COORDINATION COMPOUND OF Zn(II) ION WITH KETOROLAC

Momojon Karimova

PhD student the Khorezm Ma’mun Academy

Aybek Khudoyberganov

PhD., Senior Scientific Researcher, Khorezm Ma’mun Academy

Keywords: Ketorolak, formamid, atsetamid, karbamid, nikotinamid, kompleks birikma, aralash-ligandli kompleks birikma, metall kompleks, IR-spektroskopiya, UV-Vis, element analiz.

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Abstract

Ushbu  maqolada rux nitrat va ketorolak asosida hosil qilingan yangi koordinatsion birikmaning sintezi va fizik-kimyoviy xossalari o‘rganildi. Kompleks birikma [Zn(ket)₂](NO₃)₂•2H₂O suv va etanol aralashmasida pH = 5.5–6 sharoitida sintez qilindi. Oq kristall holida cho‘kma sifatida ajralib chiqdi. Sintez qilingan modda IR-spektroskopiya, UV-Vis va elementar analiz metodlari yordamida tahlil qilindi. Natijalar birikmada Zn–O koordinatsion bog‘lar hosil bo‘lganini, ketorolak esa karboksil guruhi orqali rux ioniga bog‘langanini ko‘rsatdi. Tadqiqot natijalari yangi koordinatsion birikmalar sintezining farmatsevtika va noorganik kimyo sohalaridagi ahamiyatini tasdiqlaydi.

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References

1. K.Jagadesh Babu , Dasari Ayodhya, Shivaraj. Comprehensive investigation of Co(II), Ni(II) and Cu(II) complexes derived from a novel Schiff base: Synthesis, characterization, DNA interactions, ADME profiling, molecular docking, and in-vitro biological evaluation // Results in Chemistry Volume 6, December 2023, 101110. https://doi.org/10.1016/j.rechem.2023.101110

2. A.H.Mohamed, H.A.R.Laila, M.A.M.Abdel-Mawgoud, K.M.Shaaban, Zinc(II) complexes derived from ibuprofen Schiff base ligands: synthesis, characterization and biological activity, Sohag J. Sci. 7 (2022) 123–130. https://doi.org/ 10.21608/sjsci.2022.151732.1013

3. R.Manikandan, P. Viswanathamurthi, K. Velmurugan, R. Nandhakumar, T. Hashimoto, A. Endo, Synthesis, characterization and crystal structure of cobalt (III) complexes containing 2-acetylpyridine thiosemicarbazones: DNA/protein interaction, radical scavenging and cytotoxic activities, J. Photochem. Photobiol. B 130 (2014) 205–216. https://doi.org/10.1016/j.jphotobiol.2013.11.008

4. M.G.Abdul, G.Kamble, R.N.Nageswara, R.Nagaraju, Structural, spectral and biological studies of (E)-2-((2-(benzo[d]thiazol-2-yl)hydrazineylidene)methyl)- 4,6-dibromophenol (HL) and its metal complexes of Mn(II) Cu(II), Co(II), Ni(II), and Zn(II), J. Results Chem. 6 (2023), 101001. https://doi.org/10.1016/j.rechem.2023.101001