Multidisciplinary Journal of Science and Technology

МЕХАНИЗМЫ РАЗВИТИЯ САРКОПЕНИИ ПРИ ЦИРРОЗАХ ПЕЧЕНИ РАЗЛИЧНОЙ ЭТИОЛОГИИ

Гадаев А.Г.

Ташкентская Медицинская Академия, Ташкент, Узбекистан

Жураева М.А.

Андижанский Государственный Медицинский Институт, Андижан, Узбекистан

Холикова Д.С.

Андижанский Государственный Медицинский Институт, Андижан, Узбекистан

Keywords: liver cirrhosis, sarcopenia, myostatine

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Abstract

The article describes the occurrence of sarcopenia in liver cirrhosis of various etiologies and the mechanisms of its development. Specifically, it presents an analysis of data from global literature on the development of sarcopenia in this disease. The article demonstrates that the mechanisms of sarcopenia development are complex and involve numerous factors, including myostatin, the rapamycin 1 complex, the ubiquitin-proteasome pathway, insulin-like growth factor-1, interleukin-6 and alcohol abuse.

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