Multidisciplinary Journal of Science and Technology

STUDYING THE WET ABSORPTION KINETICS OF THE DRY EXTRACT OF “HYPOSEDAF”

Safarova Diyora Tolibovna

Candidate of Pharmaceutical Sciences of the Tashkent Pharmaceutical Institute

Nazarova Zarifa Alimjanovna

Doctor of pharmaceutical sciences, professor of the Tashkent Pharmaceutical Institute

Maksudova Firuza Khurshidovna

Tashkent Pharmaceutical Institute, doctor of Pharmaceutical Sciences, Associate Professor

Keywords: dry extract, hygroscopicity, gravimetric method, ambient humidity, sample surface area.

---

Abstract

Hygroscopicity of dry extract "Hyposedaf" was investigated. The study was conducted in accordance with the methodology described in the European Pharmacopoeia and in accordance with its own DF 1-J. made under the conditions set out in the article. In addition, the kinetics of moisture absorption S.A.Nosovitskaya proposed and conducted a modified weighing method. Based on the results obtained, it was found that the analyzed extract belongs to the group of “hygroscopic” substances, and its moisture absorption kinetics directly depends on the relative humidity of the external environment and the surface area of the sample.

---

References

State Pharmacopoeia Of The Republic Of Uzbekistan. Toskent -2021. Volume 1, part 1-2.

European pharmacopeia 7.0, vol. 1 (general texts 5/11).

D.Y.Jalilova, E.S.Karieva. The study of the moisture-sorption properties of the dry extract “Helmintabs" // Pharmaceutical Journal.-Tashkent.-2020.-No. 1.- pp.77-80.

Turdieva Z.V., Mirakilova D.B., Azizov.U.M. Hypotensive medicinal product based on unabi fruits // Collection of the II International scientific and practical conference “Abu Ali ibn Sino and innovations in modern pharmaceuticals".-Tashkent, 2019 April 25. -pp.78-80.

Mol G.S. Studying the features of the modern pharmaceutical market of antihypertensive drugs //International Journal of Experimental Education. - 2015. – № 5-1. – pp. 143-144.

Mammadova Z.D., Fateeva T.G., Parfenov V.A. Headaches in patients with arterial hypertension and hypertensive crises // Neurological Journal.-2013.-No. 2.-pp.28-32.

R.K.Sadykova., E.S.Karieva. The study of factors affecting the hygroscopicity of the dry extract of the Samarkand immortelle // Collection of materials of the XI All-Russian scientific conference of students and postgraduates with international participation "Young pharmacy - the potential of the future".-St. Petersburg.-2021- Vol.1.-p.223-226.

Karpov Yu.A., Shubina A.T. Possibilities of optimization of hypotensive therapy: chronotherapy of nocturnal arterial hypertension //Atmosphere. Cardiology news.-2017.-No. 1.-pp.18-23.

State Pharmacopoeia of the Russian Federation, XIV ed., Moscow (2018); [Electronic resource],URL: https://femb.ru/record/pharmacopea14.

Nosovitskaya S. A., Borzunov E. E., Safiulin R. M. Production of tablets. — M.: Medicine, 1969.— 135 p.