PREGNANCY MANAGEMENT INWOMEN WITH CONGENITAL DEVELOPMENTAL FAULTS AND A HISTORY OF FROZEN PREGNANCY
Yangibaeva D.T.
epartment of Obstetrics and Gynecology in family medicine, assistant, Tashkent Medical Academy, Tashkent.
Chorieva G.Z.
Department of Obstetrics and Gynecology in family medicine, associate professor, Tashkent Medical Academy, Tashkent.
Sadullaeva U.A.
Department of Obstetrics and Gynecology in family medicine, assistant, Tashkent Medical Academy, Tashkent.
Rakhimberdieva Z.A.
Department of Internal Medicine and endocrinology #2, assistant, Tashkent Medical Academy, Tashkent.
Keywords: congenital malformations of the fetus, non-viable pregnancy, folate metabolism.
Abstract
Prognostic risk factors for the development of congenital malformations and non-viable pregnancies are: heredity, consanguinity, complicated obstetric and somatic anamnesis, viral infection, inadequate antenatal care, hypercoagulation, low qualification of functional physicians, failure to comply with screening deadlines and examination methods. Prediction of congenital malformations of the fetus and non-viable pregnancies taking into account significant antenatal factors and proper pregravidarum preparation of women will prevent the development of fetal malformations, reduce unsatisfactory fetal and perinatal outcomes, which will have a positive effect on the health of the family and the whole society.
References
1.Akhmedov M.E. Features of the main risk factors for the development of congenital heart defects // Bulletin of the NDMC. 2022. No. 2.
2.Boboev K. T., Saidzhalilova D. D., Khodjaeva D. N., Mirzaeva D. B. The role of polymorphism of thrombophilic hemostasis genes in miscarriage during in vitro fertilization (IVF) // News of dermatovenereology and reproductive health. 2020, No. 1, Tashkent pp. 61-63.
3.Demikova N.S., Podolnaya M.A., Lapina A.S. Analysis of the epidemiological picture of congenital malformations in the regions of the Russian Federation. // Medical Genetics 2020; 19(7): 31-32.
4.Demikova N.S., Podolnaya M.A., Lapina A.S. The Importance of Genetic Research in Studying the Nature of Congenital Malformations // Russian Bulletin of Perinatology and Pediatrics, 2020; 65:(5)
5.Chorieva G.Z., Sadikova D.R., Sadullaeva U.A. Metabolic therapy for placental dysfunction in pregnant women with avo-immunization.// SCHOLAR. VOLUME 1 | ISSUE 34 | 2023 December, 584-597,https://doi.org/10.5281/zenodo.10416954
6.Chorieva G.Z., Sadikova D.R., Yuldasheva D.Yu., Sadullaeva U.A., Indicators of the proteolysis process in women with placental dysfunction against the background of ABO immunization. // Vestnik TMA No. 6, 2023. 149-152
7. Palacios AM, Feiner RA, Cabrera RM. Characterization of folic acid, 5-methyltetrahydrofolate and synthetic folinic acid in the high-affinity folate transporters: impact on pregnancy and development. Reprod Dev Med. 2023 Jun;7(2):102-107.
8.Yangibayeva DT, Yuldasheva D.Yu., Sadikova DR, Choriyeva GZ, Sadullayeva UA Influence of folate cycle MTHFR gene polymorphism on the process of fetus development in residens of the republic Uzbekistan. World Bulletin of public Health Volume 22, May 2023. P 43.
9.Yangibayeva DT, Yuldasheva D.Yu., Sadikova DR, Choriyeva GZ, Sadullayeva UA Folat tsikli genlari polimorf variantlarining inson embrional rivojlanishining dastlabki bosqichlari buzilishiga ta'siri. TMA Bulletin No. 9, 2022. Pp. 141-143.
10.Yoshizato T, Kozuma Y, Horinouchi T, Shinagawa T, Yokomine M, Ushijima K. Diagnosis of Fetal Abnormalities during the First Trimester.// Kurume Med J. 2021 Jul 21;66(2):85-92. doi: 10.2739/kurumemedj.MS662002.